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Questo riguarda anche gli inibitori moderati del CYP 3A4, come aprepitant, eritromicina, fluconazolo, verapamil e diltiazem! In an embodiment, the 8-substituted tetracycline compound is 8-substituted tetracycline (eg, wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); 8-substituted doxycycline (eg, wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); or 8-substituted sancycline (wherein R 4 is NR 4′R 4″; R 4′ and R 4∝are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms. Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine: (Moderate) The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors.